The Madikwe Reserve lies within the geographical region known as the Kalahari Plains Thorn Bushveld Savanna Biome.
The average temperature throughout the year is a moderate 18 degrees Centigrade. The summer months, between September and April, range in temperature from 16 degrees Centigrade to 31 degrees Centigrade.
The winder period, May through August, fairs more temperately at between 2 degrees Centigrade and 22 degrees Centigrade.
Madikwe is classified as a summer rainfall region with the highest levels expected between November and February and the lowest between June and September